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Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis
Annals of Neurology , 09/17/09

Piepers S et al. – The finding that VPA, at a dose used in epilepsy, does not show a beneficial effect on survival or disease progression in patients with ALS has implications for future trials with histone deacetylase inhibitors in ALS and other neurodegenerative diseases. The use of a sequential trial design allowed inclusion of only half the number of patients required for a classic trial design and prevented patients from unnecessarily continuing potentially harmful study medication.

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Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
The Lancet, 11/03/09

Magnetic Resonance Imaging Predictors of Conversion to Multiple Sclerosis in the BENEFIT Study
Archives of Neurology, 11/11/09

Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure
Journal of Human Hypertension, 11/02/09

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Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA, 10/29/09

Escitalopram and Venlafaxine for the Prophylaxis of Migraine Headache Without Mood Disorders
Clinical Neuropharmacology, 10/02/09

Outcome of intracerebral haemorrhage patients pre-treated with statins
European Journal of Neurology, 11/17/09

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