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See Latest ArticlesPathogenic CD8+ T cells in multiple sclerosis
Annals of Neurology , 09/16/09
Friese MA et al. – Several clinical trials of monoclonal antibodies specifically against CD4+ T cells, or the polarizing cytokines on which they depend, have failed to show any therapeutic benefit in MS, unlike broader–spectrum antibodies that deplete all T cells. Here, the authors review the evidence that CD8+ T cells play a role in MS pathogenesis.
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