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See Latest ArticlesIntranasal delivery of ESBA105, a TNF-alpha-inhibitory scFv antibody fragment to the brain
Journal of Neuroimmunology, 09/14/09
Furrer E et al. – Although a 10–fold higher dose was given intranasally, systemic exposure was about 33–fold lower for the intranasal route than following systemic application. Addition of a penetration enhancing peptide to the formulation enhanced the delivery of ESBA105 to the olfactory bulb and the cerebrum, without increasing systemic exposure.
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Gabapentin Enacarbil in Restless Legs Syndrome: A Phase 2b, 2-Week, Randomized, Double-Blind, Placebo-Controlled Trial
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