Neurology

Your Article Summary

See Latest Articles

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies
Drugs & Aging, 09/08/09

Samii A et al. – NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.

• The authors systematically searched MEDLINE (1966–November 2008), EMBASE (1980–November 2008) and other databases.
• Data from 11 studies were included in the meta–analysis.
• The authors used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs).

• The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12).
• The pooled risk ratio of PD with high–dose or long–duration NSAID use was 0.91 (95% CI 0.78, 1.05).
• The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26).
• The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89).
• The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15).

Related Articles

See all related articles

Nonsteroidal anti-inflammatory drugs
Cancer, 10/16/09    Relevance Score: 91%

Effect of nonsteroidal anti-inflammatory drug plasters for knee osteoarthritis in Japanese: a randomized controlled trial
Modern Rheumatology, 10/12/09    Relevance Score: 89%

Perioperative Use of Nonsteroidal Anti-Inflammatory Drugs: Results of a UK Regional Audit
Clinical Drug Investigation, 10/15/09    Relevance Score: 88%

Use of Nonsteroidal Antiinflammatory Drugs and Risk of Endometrial Cancer
American Journal of Epidemiology, 11/09/09    Relevance Score: 85%

Ophthalmic utility of topical bromfenac, a twice-daily nonsteroidal anti-inflammatory agent
Expert Opinion in Pharmacotherapy, 10/19/09    Relevance Score: 85%

Today in Movement Disorders...keeping you current

Receive free subspecialty "5-minute updates" via email

Enhanced frontal function in Parkinson’s disease
Brain, 12/18/09

Hereditary spastic paraplegia caused by the PLP1 "rumpshaker mutation"
Journal of Neurology, Neurosurgery, and Psychiatry , 12/18/09

Impaired sensorimotor integration in focal hand dystonia patients in the absence of symptoms
Journal of Neurology, Neurosurgery, and Psychiatry , 12/18/09

 See all of Movement Disorders