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The Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants
Trends in Pharmacological Sciences, 09/15/09

Hill MN et al. – Within preclinical models, facilitation of endocannabinoid neurotransmission evokes both antidepressant and anxiolytic effects. Similar to the actions of conventional antidepressants, enhancement of endocannabinoid signaling can enhance serotonergic and noradrenergic transmission; increase cellular plasticity and neurotrophin expression within the hippocampus; and dampen activity within the neuroendocrine stress axis.

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When starting an antidepressant, try either of these 2 drugs first
APCToday, 11/20/09 Relevance Score: 88%

Explaining Racial and Ethnic Differences in Antidepressant Use Among Adolescents
Medical Care Research and Review, 11/18/09 Relevance Score: 87%

The Role of Sodium Channels in the Mechanism of Action of Antidepressants and Mood Stabilizers
Current Drug Targets, 10/30/09 Relevance Score: 87%

Increase In Long-term Antidepressant Drug Use, UK Study Reveals
ScienceDaily, 10/26/09 Relevance Score: 87%

Study reveals an increase in long-term antidepressant drug use
EurekAlert, 10/23/09 Relevance Score: 87%