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Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine
Cephalalgia, 09/08/09
Silberstein SDe et al. – Tonabersat was generally well tolerated, with dizziness and nausea the most common side–effects. Serious adverse events were uncommon, and no patient withdrew from either study because of adverse events. These results suggest a possible interplay between tonabersat pharmacokinetics (the relatively long time required to reach maximum plasma concentrations) and patient characteristics (previous triptan exposure) in the management of acute migraine attacks. Based on the pharmacokinetics and actions on cortical spreading depression, tonabersat may have potential value in migraine prophylaxis.
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Epidemiology of headache in Arab countries
The Journal of Headache and Pain, 12/04/09
Economic Evaluation of Pharmacotherapy of Migraine Pain: A Review of the Literature
Journal Of Pain & Palliative Care Pharmacotherapy, 12/02/09
The validity of questionnaire-based diagnoses: the third Nord-Trondelag Health Study 2006-2008
The Journal of Headache and Pain, 12/01/09
Today in Pain Medicine...keeping you current
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Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials
The Lancet, 12/07/09
Simulated acupuncture and real acupuncture both reduced low back pain dysfunction and symptoms
Evidence-Based Medicine, 12/07/09
Review: evidence for the effectiveness of non-surgical interventions for low back pain and radiculopathy is limited
Evidence-Based Medicine, 12/07/09
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