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See Latest ArticlesTalampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial
Journal of Clinical Oncology, 09/02/09
Grossman SA et al. – Talampanel can be added to RT + TMZ without significant additional toxicity. The encouraging survival results in methylated and unmethylated patients suggest that blocking AMPA receotirs nat be a ysefyk strategy in newly diagnosed glioblastoma.
Methods- 72 patients with glioblastomas treated with talampanel + RT and TMZ
- Median f/u 18 mos
- 55 patients died
- Median survival time of 18.3 mos
- Talampanel was well-tolerated
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