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Kverno KS et al. – Most studies of interventions for dementia–related NPS have focused on individuals with mild to moderate cognitive impairment. Individuals with severe cognitive impairment do not necessarily respond to NPS treatments in the same manner. Future studies should be specifically designed to further explore the stage–specific efficacy of non–pharmacological therapies for patients with advanced dementia. Areas of particular need for further research include movement–based therapies, hands–on (touch) therapies, and interventions that can be provided during personal care routines. Interventions appear to work best when they are tailored to balance individual arousal patterns.

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