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Cortisol Metabolism in Depressed Patients and Healthy Controls
Neuroendocrinology, 08/28/09
Römer B et al. – The results show changes in activity of intracellular modulators of steroid action in major depressive disorders, particularly a reduced activity of the intracellular cortisol–deactivating enzymes 5–alpha–reductase and 11–HSD2. These changes suggest an increase in cortisol bioavailability within tissues.
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