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What can be learned from the history of recurrence in migraine? A comment
The Journal of Headache and Pain, 08/27/09
Tfelt–Hansen P – Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribed to patient–dependent factors but experience with ergot alkaloids suggested that recurrence can also be treatment–dependent. Possible mechanisms for recurrence are discussed.
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