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Pharmacokinetics of carboplatin and etoposide in infant neuroblastoma patients
Cancer Chemotherapy and Pharmacology, 08/26/09
Veal GJ et al. – Results suggest that prediction of absolute carboplatin Cl values may be difficult in infant patients <12 kg, with a small but significant difference in Cl values normalized to BW observed in this patient group. Etoposide pharmacokinetic data support previous findings that question the utility of modified dosing in infants. The current study demonstrates the feasibility of generating informative pharmacokinetic data in infants and young children.
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