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See Latest ArticlesSevere ataxia with neuropathy in hereditary gelsolin amyloidosis
Amyloid The Journal of Protein Folding Disorders, 08/28/09
Tanskanen M et al. – The report shows that advanced AGel amyloidosis due to degeneration of central and distal sensory nerve projections results in deleterious ataxia with fatal outcome. Severe posterior column atrophy may reflect radicular AGel deposition, although even altered gelsolin – actin interactions in neural cells possibly contribute to neurodegeneration with successive ataxia in carriers of a G654A gelsolin mutation.
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