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See Latest ArticlesDual-Targeted Antitumor Effects Against Brainstem Glioma By Intravenous Delivery of Tumor Necrosis Factor-Related, Apoptosis-Inducing, Ligand-Engineered Human Mesenchymal Stem Cells
Neurosurgery, 08/25/09
Yang B et al. – Systematically transplanted MSCs migrated to gliomas with a high specificity. Systematic delivery of MSC–hTRAIL can prolong the survival of brainstem glioma–bearing mice, presumably through a dual–targeted effect of membrane–spanned, TRAIL–engineered MSCs in the tumor microenvironment. MSCs may be an effective vehicle for the targeted delivery of therapeutic agents to brainstem gliomas.
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