Neurology Medical News about d-Cycloserine nicotine dependent smokers

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d-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: A pilot investigation
Drug and Alcohol Dependence, 08/19/09

Santa Ana EJ et al. – These findings provide promising support for DCS combined with cue exposure therapy in attenuating conditioned reactivity to smoking cues.

Methods

Double–blind placebo–controlled pilot laboratory study
25 smokers were recruited from the general community and randomized to DCS or placebo, plus cue exposure therapy.

Results

DCS significantly attenuated smoking cue reactivity in response to in–vivo smoking cues based on physiological reactivity and subjective urge–to–smoke ratings and led to a significantly smaller expired carbon monoxide (CO) level at the one–week follow–up compared to placebo, although exploratory analyses indicated no effect on smoking behavior overall.

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