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See Latest ArticlesThe prognosis of fixed dystonia: A follow-up study
Parkinsonism & Related Disorders, 08/21/09
Ibrahim NM et al. – Findings show poor prognosis for fixed dystonia, with improvement in <25% of pts, major remission in 6%, and continued worsening in 33%. Also reported is a high rate of neuropsychiatric findings and new neuropsychiatric features in some pts. The average health status was poor. Of the baseline parameters, only complex regional pain syndrome (CRPS) predicted poorer outcome.
Methods- Clinical and neuropsychiatric follow-up study by telephone and self-administered instruments (HADS, SDQ-20, DES II, EQ-5D) for 41 pts with fixed dystonia after mean of 7.6 (±3.6) yrs
- Review of data for clinical outcome in 35 (85.4%) pts and neuropsychiatric questionnaire data in 22 (53.7%); 83% women
- Status worsened for 31%, same for 46%, improved for 23%, of whom 6% had major remissions
- Mean duration of illness: 11.8 (±4.9) yrs
- Mean age 43.2 (±14.8) yrs
- Diagnosis remained unchanged except for 1 pt re-diagnosed with corticobasal degeneration
- Scores indicating anxiety for 41%; depression for 18% indicating
- Scores within range of dissociative/somatoform disorders on DES II for 18% and on SDQ-20 for 19%
- Mean EQ-5D index: 0.34
- Mean VAS score: 56.1%
- Significant difference in the EQ-5D only on comparison between the 3 outcome groups
- Only baseline CRPS predicted worse outcome
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