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Parkinson's disease dementia -- A diminished role for the Lewy body
Parkinsonism & Related Disorders, 08/21/09

Libow LS et al. – Findings do not support the hypothesis that Lewy bodies (LBs) are the main substrate for dementia in of Parkinson's disease (PD). More research with a larger sample size must determine whether the LB may be a secondary phenomenon and/or an “innocent-bystander”, as the entire role of LB in PD dementia is undetermined.

Methods

Study to characterize pathological features of PDD in 18 PD brain specimens by published criteria for AD, diffuse LB disease (DLBD), and vascular disease as a framework

Results

Among 16 PD dementia subjects, 3 (19%) did not have LBs outside of the brain stem and did not have AD or vascular pathology
Of 2 additional cases that did not meet DLBD diagnostic criteria, 1 pt had rare LBs in neocortex and cingulate gyrus
Remaining PD dementia subjects had a classic pathological profile consistent with AD (38%), vascular disease (12.5%), DLBD (6%), or a combination of these pathologies (12.5%)

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