Neurology Medical News about fMRI, putamen, basal ganglia, levodopa, Parkinson's disease

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Levodopa-induced striatal activation in Parkinson's disease: A functional MRI study
Parkinsonism & Related Disorders, 08/21/09

Kraft E et al. – Results show that the putamen and thalamus are the regions within the cortico-subcortical motor-circuit with most prominent response to levodopa. Cortical motor areas did not respond to levodopa expected from previous studies. These findings support evidence that an extended model of the underlying pathophysiology of motor dysfunctions in Parkinson's disease (PD) is warranted.

Methods

Study of the effect of a single levodopa dose (200 mg levodopa, 50 mg carbidopa [sdLD]) on cortical and subcortical motor-circuit activation during bimanual grip force in PD pts
Assessment of 12 right-handed PD pts (Hoehn–Yahr stages I–II) after ≥12 hr without medication (OFF state) and 1 hr after oral administration of sdLD (ON state) by functional magnetic resonance imaging (fMRI)
Measurement of blood-oxygenation-level-dependency (BOLD) fMRI while pts had 2 unilateral and 2 bimanual grip force movements with defined movement amplitude and force (10N) in block design
Controls: 12 age-matched healthy pts without sdLD administration

Results

Bimanual grip force tasks activated a specific pattern of cortical and subcortical structures in all pts during OFF state and after levodopa administration
Statistically significant differences in putamen and thalamus for OFF vs ON condition
No such significant changes in cortical structures
Higher putaminal activity in controls vs OFF state in bimanual tasks; differences disappeared after levodopa administration

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