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See Latest ArticlesContinuous positive airway pressure treatment for obstructive sleep apnoea reduces resting heart rate but does not affect dysrhythmias: A randomised controlled trial
Journal of Sleep Research, 08/21/09
Craig S et al. – Findings for an obstructive sleep apnea (OSA) study show that 4 wks of continuous positive airway pressure (CPAP) therapy reduces mean 24-hr heart rate, possibly due to reduced sympathetic activation, but did not result in a significant decrease in dysrhythmia frequency.
Methods- Randomized controlled trial of therapeutic CPAP vs subtherapeutic control
- Subtherapeutic control: exploration of changes in dysrhythmia frequency and heart rate
- Subjects: 83 men [49.5 (mean SD 9.6) yrs] with moderate-severe OSA
- 3-channel 24-hr electrocardiograms during normal daily activities, before/after 1 mo of CPAP therapeutic (43 pts) or subtherapeutic (40 pts)
- Moderate-severe OSA: Oxygen Desaturation Index, 41.2 (24.3) dips/hr
- Recordings manually analyzed for mean heart rate, pauses, bradycardias, supraventricular and ventricular dysrhythmias
- Group matching: age, body mass index, OSA severity, cardiovascular risk factors, history
- Supraventricular ectopics and ventricular ectopics frequent in 95.2% and 85.5% of pts, respectively
- Less common: sinus pauses (42.2%), episodes of bradycardia (12%) and ventricular tachycardias (4.8%)
- CPAP reduced mean 24-hr heart rate from 83.0 (11.5) to 79.7 (9.8) in CPAP group vs non-significant rise from 79.0 (10.4) to 79.9 (10.4) in subtherapeutic group; also true for day period analyzed separately
- No significant change in dysrhythmia frequencies after CPAP
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