Neurology Medical News about Niemann-Pick, spiral analysis, motorphysiology

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Spiral analysis in Niemann-Pick disease type C
Movement Disorders, 08/19/09

Hsu AW et al. – Findings show that differing aspects of tremor, Parkinsonism, ataxia, and dystonia are quantifiable in pts with Niemann-Pick disease type C (NPC).

Methods

Spiral analysis: computerized method of analyzing upper limb motor physiology through quantification of spiral drawing
Study of whether spirals drawn by NPC pts vs by controls are distinct
Physiological characterization of movement abnormalities in NPC
Assessment of spiral data: position, pressure, time
Subjects: 14 NPC pts and 14 age-matched controls
Analysis by Mann-Whitney U test

Results

NPC spiral characterization: lower speed (2.67 vs 9.56 cm/s) and acceleration (0.10 vs 2.04 cm/s2), higher loop width variability (0.88 vs 0.28), tremor (5/10 vs 0/10 trials in dominant hand), and poor overall spiral rating (2.53 vs 0.70)
NPC spirals: sustained drawing pressure profiles abnormally invariant with time
Normal other features: tightness of loop widths

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