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See Latest ArticlesOligomerization partially explains the lowering of a β42 in Alzheimer’s disease cerebrospinal fluid
Neurodegenerative Diseases, 08/17/09
Englund H et al. – Combining denaturing and non-denaturing quantifications of Abeta42 into an oligomer ratio enables assessment of Abeta oligomers in biological samples. The increased Abeta42 oligomer ratio for Alzheimer's disease (AD) and mild cognitive impairment (MCI) indicates the presence of oligomers in cerebrospinal fluid (CSF) and oligomerization causes lowering of natively measured Abeta42.
Methods- Study of whether oligomerization causes lowering of CSF Abeta42 in AD pts
- Analysis of Abeta42 under both denaturing and non-denaturing conditions
- Calculation of an Abeta42 oligomer ratio
- Abeta42 oligomer ratio to assess oligomerized Abeta in human CSF after evaluation in transgenic mouse brain homogenates
- AD and MCI showed expected decrease in natively measured Abeta42 vs healthy controls and frontotemporal dementia, but not on analysis under denaturing conditions
- AD and MCI CSF had higher Abeta42 oligomer ratio in CSF
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