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Lim AS et al. – This studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM–promoting and REM–inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep.

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