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Quest for a broad-range vaccine against Neisseria meningitidis serogroup B: implications of genetic variations of the surface-exposed proteins
Journal of Medical Microbiology, 09/02/09
De Filippis I et al. – The continuous adaptation of surface meningococcal structures to the external environment has led to genetic shifts of potential vaccine–target epitopes, hampering the quest for a broad–range vaccine that could be used against all serogroups, especially against serogroup B.
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