Neurology Medical News about hyperkinetic movement disorders, treatment, basal ganglia

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Treatment of hyperkinetic movement disorders
The Lancet Neurology, 08/13/09

Jankovic J et al. – A review of treatment for hyperkinetic movement disorders focuses on the pathophysiology and summarizes the pharmacological and surgical approaches to treatment.

Methods

Review of treatment for hyperkinetic movement disorders

Results

Hyperkinetic movement disorders: tremors, dystonia, chorea, tics, myoclonus, stereotypies, restless legs syndrome, and other disorders with abnormal involuntary movements
Substantial progress in understanding of the role of basal ganglia in pathophysiology of hyperkinesia disorders and in motor control, muscle tone, posture, and cognitive processes
Lack of therapies to target pathogenesis
Effective management of these disorders mandates knowledge of current and novel pharmacological and surgical approaches
Increasing use of new formulations of botulinum toxin, in addition to tetrabenazine, a monoamine-depleting drug
Successful use of surgical approaches (eg, deep brain stimulation for levodopa-induced dyskinesias in Parkinson's disease) for treatment of many hyperkinetic movement disorders

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