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Exclusive breastfeeding and the risk of postpartum relapses in women with multiple sclerosis
Archives of Neurology, 08/13/09
Langer-Gould A et al. – Findings suggest that exclusive breastfeeding and concomitant suppression of menses significantly reduce risk of postpartum relapses in multiple sclerosis (MS). These findings question the benefit of foregoing breastfeeding to start MS therapies, pending confirmation in a larger study.
Methods- Study of whether exclusive breastfeeding protects against postpartum relapses of MS
- Evaluation of whether this protection is related to prolonged lactational amenorrhea
- Structured interviews to assess clinical, menstrual, and breastfeeding history during each trimester and 2, 4, 6, 9, and 12 mo postpartum
- Review of neurologic examination findings from treating physicians of women with MS
- Prospective enrollment of 32 pregnant women with MS and 29 age-matched, pregnant controls
- Main outcome measure: postpartum relapse
- Postpartum relapse for 87% of the 52% of MS pts who did not breastfeed or began regular supplemental feedings within 2 mo postpartum vs 36% of MS pts who breastfed exclusively for ≥2 mo postpartum
- Resumption of MS therapies was primary reason for foregoing exclusive breastfeeding for 60% of pts
- Menses return later for women who breastfed exclusively vs did not breastfeed exclusively
- Lactational amenorrhea associated with reduced risk of postpartum relapses for women who breastfed exclusively vs did not breastfeed exclusively
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