Neurology Medical News about multiple sclerosis, chemokine, interferon beta therapy

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Enhancement of chemokine expression by interferon beta therapy in patients with multiple sclerosis
Archives of Neurology, 08/13/09

Cepok S et al. – Findings in multiple sclerosis (MS) pts show that interferon beta strongly upregulates a set of chemokines and CCR1 in peripheral immune cells. Peripheral upregulation of these chemokines may reduce the chemoattraction of immune cells to the central nervous system and thus add to the therapeutic effects of interferon beta.

Methods

Study of the influence of interferon beta on chemokine expression and receptors in MS
Quantitative real-time polymerase chain reaction from fresh blood samples for expression of 14 chemokines and 14 chemokine receptor genes
Setting: outpatient units in Germany
Subjects: untreated and interferon beta–treated MS pts positive/negative for neutralizing antibodies (NABs)
Main outcome measures: gene expression and serum chemokine protein levels

Results

CCL1, CCL2, CCL7, CXCL10, CXCL11, and CCR1 gene expression strongly upregulated in interferon beta–treated, NAB-negative MS pts
Gene expression in interferon beta–treated, NAB-positive MS pts did not differ from untreated control donor pts
Antibody titers inversely correlated with chemokine and chemokine receptor gene expression
Serum chemokine protein levels significantly higher for interferon beta–treated, NAB-negative MS pts vs untreated or interferon beta–treated, NAB-positive MS pts

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