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Evidence of shared genetic risk factors for migraine and rolandic epilepsy
Epilepsia, 08/12/09

Clarke T et al. – Migraine is strongly comorbid in rolandic epilepsy (RE) and independently clusters in these siblings. These results suggest shared susceptibility to migraine and RE that is not directly mediated by epileptic seizures. Susceptibility gene variants for RE may be tested as risk factors for migraine.

Methods

Study of migraine risk in RE probands and their siblings
Cohort and reconstructed cohort designs to respectively assess relative risk of migraine in 72 children with RE and their 88 siblings
Use of International Classification of Headache Disorders (ICHD-2) criteria
Comparison of incidence in 150 age- and geographically matched nonepilepsy probands and their 188 siblings
Cox proportional hazards model, using age as time base
Adjustment for hazard ratios (HRs) for sex in proband analysis and for sex and proband migraine status in sibling analysis

Results

Prevalence of migraine: 15% for RE probands vs 7% for nonepilepsy probands; 14% for siblings of RE probands prevalence vs 4% in nonepilepsy siblings
Sex-adjusted HR of migraine for RE proband: 2.46
Adjusted HR of ≥1 sibling with migraine in RE family: 3.35
Adjusted HR of any 1 sibling of RE proband: 2.86

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