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Relation of candidate genes that encode for endothelial function to migraine and stroke. The Stroke Prevention in Young Women Study
Stroke, 08/18/09
MacClellan LR et al. – Variants in endothelin-1 (EDN) and endothelin receptor type B (EDNRB) were associated with stroke susceptibility in white but not in black women. Results show no evidence that these genes mediate the association between migraine and stroke.
Methods- Study of whether polymorphisms in genes regulating endothelial function confer susceptibility to migraine and stroke
- Genes studied: EDN, EDNRB, nitric oxide synthase-3 (NOS3)
- Use of data from the Stroke Prevention in Young Women study
- Stroke Prevention in Young Women study: population-based case-control study of 297 women age 15-49 yrs with ischemic stroke and 422 women without stroke
- EDN SNP rs1800542, rs10478723, EDNRB SNP rs4885493, rs10507875 associated with increased stroke susceptibility in whites
- Only 1 of the tested SNP (NOS3 rs3918166) was associated with both migraine and stroke
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