Neurology

Your Article Summary

See Latest Articles

Elevated cerebrospinal fluid and plasma homocysteine levels in ALS
European Journal of Neurology, 08/03/09

Valentino F et al. – Homocysteine (HC) is a biochemical marker in amyotrophic lateral sclerosis (ALS) and may be related to the disease pathophysiology.

• Assay the cerebrospinal fluid (CSF) and plasma levels of HC in ALS pts and controls
• Evaluation of relationship between HC levels and clinical disease variables
• CSF from 69 (M/F 1.87) and plasma from 65 ALS pts (M/F 1.83)
• Storage at -80 degrees C until use
• Controls (55 CSF; 67 plasma): pts admitted to hospital for neurological disorders with no known relationship to HC changes
• CSF and plasma from ALS pts and controls obtained as a key step of diagnostic workup
• HC levels in CSF and plasma assayed by high performance liquid chromatograph (HPLC) and a fluorimeter detector

• Median level of total HC in CSF of ALS pts: 0.46 microM, significantly higher vs controls (0.24 microM, +91.6%)
• Similar trend for HC assayed in plasma (ALS, 12.4 microM vs controls, 7.26 microM, +70.8%)
• CSF and plasma HC levels showed no relationship with disease progression, onset age, and onset site

Related Articles

See all related articles

Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
European Journal of Neurology, 10/12/09    Relevance Score: 64%

In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses
Acta Neurologica Scandinavica, 10/08/09    Relevance Score: 64%

Circulating CSF-1 Promotes Monocyte and Macrophage Phenotypes that Enhance Lupus Nephritis
Journal of the American Society of Nephrology, 11/20/09    Relevance Score: 45%

Current and emerging treatments for amyotrophic lateral sclerosis
Neuropsychiatric Disease and Treatment, 11/11/09    Relevance Score: 45%

Different Doses of Oral Folic Acid for Homocysteine-Lowering Therapy in Patients on Hemodialysis: A Randomized Controlled Trial
Iranian Journal of Kidney Diseases, 10/13/09    Relevance Score: 45%

Today in Basic Science/Genetics...keeping you current

Receive free subspecialty "5-minute updates" via email

A family with autosomal dominant leukodystrophy linked to 5q23.2–q23.3 without lamin B1 mutations
European Journal of Neurology, 12/18/09

The effect of repeated administrations of granulocyte colony stimulating factor for blood stem cells mobilization in patients with progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy
Clinical Neurology and Neurosurgery, 12/18/09

Measuring cortisol and DHEA in fingernails: A pilot study
Neuropsychiatric Disease and Treatment, 12/18/09

 See all of Basic Science/Genetics

Today in Demyelinating Disorders...keeping you current

Receive free subspecialty "5-minute updates" via email

Rasch Validation of the Falls Prevention Strategies Survey
Archives of Physical Medicine and Rehabilitation, 12/18/09

An uncommon illness with a rare presentation: neurosurgical management of ADEM with tumefactive demyelination in children
Child's Nervous System, 12/18/09

Modafinil for multiple sclerosis fatigue: Does it work
Clinical Neurology and Neurosurgery, 12/18/09

 See all of Demyelinating Disorders