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Resuscitation with Hypertonic Saline–Dextran Reduces Serum Biomarker Levels and Correlates with Outcome in Severe Traumatic Brain Injury Patients
Journal of Neurotrauma, 07/30/09

Baker AJ et al. – HSD–resuscitated patients with favorable outcomes exhibited the lowest serum S100B and NSE concentrations, while maximal levels were found in NS–treated patients with unfavorable outcomes. The lowest biomarker levels were seen in survivors resuscitated with HSD, while maximal levels were in NS–resuscitated patients with fatal outcome. Pre–hospital resuscitation with HSD is associated with a reduction in serum S100B, NSE, and MBP concentrations, which are correlated with better outcome after severe TBI.

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