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Clinical assessment of topiramate therapy in patients with migrainous vertigo
Headache: The Journal of Head and Face Pain, 07/31/09

Gode S et al. – Overall topiramate was effective in reducing the frequency and severity of vertigo and headache attacks. Both drug doses were equally efficacious. The 50-mg/day dose may be preferable as higher adverse effects were noted with the 100-mg/day dose.

• Study of topiramate efficacy to reduce both vertigo frequency and severity and headache attacks in pts with migrainous vertigo
• Comparison of 50-mg/day and 100-mg/day doses
• Assessment of 30 pts diagnosed with definite migrainous vertigo
• Determination of vertigo and headache frequency as monthly number of attacks
• Determination of severity by visual analog scales measured 0 to 100 mm
• Randomization of pts to either 50 or 100 mg/day topiramate for 6 mo
• Evaluation of vertigo and headache frequency and severity at the end of study period

• Number of monthly vertigo attacks and monthly headache attacks decreased significantly in overall group after treatment
• Statically significant improvement in vertigo severity
• Headache severity showed significant improvement
• No statistically significant difference between high- and low-dose groups regarding efficacy
• Treatment discontinued due to adverse effects in 4 pts in high-dose group at end of first month

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