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See Latest ArticlesPotential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis
Journal of Neuroimmunology, 08/04/09
Cameron EM et al. – The authors identified a unique antibody gene mutation pattern in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
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