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Sustained release of neuron-specific enolase to serum in amateur boxers
Brain Injury, 07/30/09

Zetterberg H et al. – The more than doubled median serum level of neuron-specific enolase (NSE) in boxers after an extended resting period suggests that repetitive head trauma results in sustained release of this brain-specific protein to the peripheral circulation.

Methods

Study of the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers vs healthy controls without any history of head trauma
Research design: observational case-control study
Measurement of a panel of serum biomarkers by a novel biochip array technique on the Evidence Investigator
Serum samples after a 2-mo period of nonparticipation in boxing

Results

Boxers had higher serum levels of NSE but unchanged levels of other brain damage biomarker candidates, S-100B, brain-derived neurotrophic factor and heart-type fatty acid binding protein

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