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See Latest ArticlesOvarian hormones and pain response: A review of clinical and basic science studies
Gender Medicine, 07/28/09
Martin VT – In the clinical studies reviewed, most pain disorders were reported to worsen during the late luteal and early follicular phases of the menstrual cycle. Pain thresholds and tolerance times also varied during different phases of the menstrual cycle in healthy premenopausal women in the majority of studies. Basic science studies suggested that ovarian hormones have distinct effects – on inflammation, affective states, stress responses, modulatory pain systems, and afferent sensory systems – that increase or decrease pain reactivity. Fluctuations of ovarian hormones in the course of the menstrual cycle appear to be associated with a mild to moderate effect on pain response. Greater knowledge of the mechanisms by which ovarian hormones modulate pain would broaden our understanding of why pain disorders are more frequent, severe, and disabling in women than in men.
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