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See Latest ArticlesAssociation of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population
Journal of Neuroimmunology, 07/27/09
Mirowska-Guzel D et al. – Results suggest that MMP9 -1562 C>T and MMP12 -82 A>G polymorphisms affect susceptibility to multiple sclerosis.
Methods- Study of the single nucleotide polymorphisms in human MMP genes and their impact on multiple sclerosis risk and disease progression in a Polish population
- MMP genes: MMP1 (-1637 1G>2G), MMP3 (-1612 5A>6A), MMP9 (-1562 C>T), and MMP12 (-82 A>G)
- Increased risk of MS among carriers of ≥1 T allele of MMP9 -1562 C>T and 1 G allele of MMP12 -82 A>G
- Association detected between MMP9 genotype and MMP-9 levels in peripheral blood
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