Neurology Medical News about multiple sclerosis, physiotherapy, exercise, Multiple Sclerosis Impact Scale

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Getting the balance right: A randomised controlled trial of physiotherapy and exercise interventions for ambulatory people with multiple sclerosis
BMC Neurology, 07/21/09

Coote S et al. – An ongoing randomized controlled trial will analyze data for ambulatory multiple sclerosis (MS) pts trial undergoing physiotherapy and exercise. Sub-group analysis is pending sufficient pt recruitment.

Methods

Multi-center, single-blind, block randomized, controlled trial
Pt recruitment via t 10 regional offices of MS Ireland
Telephone screening for eligibility and stratification by mobility section of the Guys Neurological Disability Scale
Randomization after a block of subjects of the same strand in the same geographical region have consented
Strand A: MS pts who walk independently or use 1 stick to walk outside
Strand A randomization to yoga, physiotherapist-led exercise class, fitness instructor-led exercise class. or control group with no change in exercise habits
Strand B: MS pts who walk with bilateral support or a rollator or who use a wheelchair for longer distance outdoors
Strand B randomization to 1:1 physiotherapist-led intervention, group intervention led by physiotherapist, group yoga intervention or control group with no change in exercise habits
Physiotherapist assessment; blind to group allocation at wk 1, wk 12 (after 10 wks intervention or control), and at 12-wk follow up
Primary outcome measure for both strands: Multiple Sclerosis Impact Scale
Secondary outcomes: Modified Fatigue Impact Scale, 6-Minute Walk test, and muscle strength measured with hand-held dynamometry
Strand B additional tests: Berg Balance Test and Modified Ashworth Scale
Recording at initial assessment of confounding variables: sensation, coordination, proprioception, range of motion and other impairments