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See Latest ArticlesMultiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1
Journal of Neuroimmunology, 07/17/09
Enevold C et al. – Results support previous findings of associations between the IFIH1-locus and multiple sclerosis (MS).
Methods- Study of whether pattern recognition receptors of the innate immune system are of pathogenic importance
- Creation of 2 novel assays to analyze 42 single-nucleotide polymorphisms in human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1
- Genotyping of 963 MS pts and 960 controls
- Evaluation for possible associations with MS diagnosis, clinical course, severity, and age at onset
- Associations between IFIH1-locus and MS are confirmed
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