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See Latest ArticlesAntibodies against interferon-beta in multiple sclerosis
Journal of Neuroimmunology, 07/13/09
Aarskog NK et al. – Real-time polymerase chain reaction (PCR) offers several advantages for measuring neutralizing antibody (NAB) vs the myxovirus-resistant protein A (MxA) protein induction enzyme-linked immunosorbent assay and should be used routinely for NAB among pts with multiple sclerosis (MS) using interferon-beta (IFN-beta) treatment.
Methods- Measurement of the frequency of binding antibody (BAB) and NAB against IFN-beta in sera from 827 relapsing-remitting MS (RRMS) c using various IFN-beta medications
- MxA protein induction assay (ELISA) and MxA messenger RNA (mRNA) induction assay (real-time PCR) for analysis of 137 BAB-positive sera for BAB
- Test of all 363 sera by real-time PCR
- Of the 827 pts, 363 (43.9%) had serum BAB after >12 mo of IFN-beta treatment
- Similar results for each serum in both NAB assays, indicating good correlation between MxA transcription and translation
- NAB present in 70.8% of BAB-positive sera, or 31.1% of the 827 pts with RRMS
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Micro-ribonucleic acid profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
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Micro-ribonucleic acid profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
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