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Burton JM et al. - Among the pertinent literature, only four studies met the inclusion criteria, comprising a total of 167 participants. All the studies found that there were no differences in clinical, pharmacological or radiological outcomes in the patients taking oral or intravenous steroids for relapses. Nevertheless, some limitations in the studies analysed suggest that a definitive conclusion is premature and more rigorous study designs will better address the question of equivalence.

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