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The cortical innate immune response increases local neuronal excitability leading to seizures
Brain, 07/01/09
Rodgers KM et al. - The results suggest an important role of innate immunity in epileptogenesis and focus on glial inhibition, through pharmacological blockade of TLR4 and the pro-inflammatory mediators released by activated glia, in the study and treatment of seizure disorders in humans.
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