Neurology Medical News about mild brain traumatic brain injury;abnormal regional benzodiazepine receptor uptake

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Abnormal regional benzodiazepine receptor uptake in the prefrontal cortex in patients with mild traumatic brain injury
Journal of Rehabilitation Medicine, 07/02/09

Hashimoto K et al. – A 123I-iomazenil single photon emission computerized tomography (SPECT) study shows focally altered benzodiazepine receptor uptake in the prefrontal cortices in pts with mild traumatic brain injury (TBI).

Methods

Study of possible abnormalities in benzodiazepine receptor uptake in brains of pts with mild TBI
SPECT for 9 unmedicated pts with mild TBI and 5 matched controls
SPECT scan 180 min after tracer injection

Results

Significant increase in benzodiazepine receptor uptake in prefrontal cortex for all 9 pts vs controls (>2 standard deviations higher than mean for controls)
Significantly higher frontal association cortex-to-average global brain activity ratios for all 9 pts vs controls

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