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Novel drug delivery strategies in neuro-oncology
Neurotherapeutics, 07/01/09

Bidros DS et al. - In a review of novel drug delivery strategies in neuro-oncology, this article will describe the clinically available methods used to circumvent the blood brain barrier and summarize results to date of ongoing and completed clinical trials.

Methods

Treatment of malignant gliomas represents 1 of the most formidable challenges in oncology.
Despite treatment with surgery, radiation therapy, and chemotherapy, the prognosis remains poor, particularly for glioblastoma, which has a median survival of 12 to 15 mos.
An important impediment to finding effective treatments for malignant gliomas is the presence of the blood brain barrier, which serves to prevent delivery of potentially active therapeutic compounds.

Results

Multiple efforts are focused on developing strategies to effectively deliver active drugs to brain tumor cells.
Blood brain barrier disruption and convection-enhanced delivery have emerged as leading investigational delivery techniques for treatment of malignant brain tumors.
Clinical trials using these methods have been completed, with mixed results, and several more are being initiated.

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