Your Article Summary
See Latest ArticlesNovel drug delivery strategies in neuro-oncology
Neurotherapeutics, 07/01/09
Bidros DS et al. - In a review of novel drug delivery strategies in neuro-oncology, this article will describe the clinically available methods used to circumvent the blood brain barrier and summarize results to date of ongoing and completed clinical trials.
Methods- Treatment of malignant gliomas represents 1 of the most formidable challenges in oncology.
- Despite treatment with surgery, radiation therapy, and chemotherapy, the prognosis remains poor, particularly for glioblastoma, which has a median survival of 12 to 15 mos.
- An important impediment to finding effective treatments for malignant gliomas is the presence of the blood brain barrier, which serves to prevent delivery of potentially active therapeutic compounds.
- Multiple efforts are focused on developing strategies to effectively deliver active drugs to brain tumor cells.
- Blood brain barrier disruption and convection-enhanced delivery have emerged as leading investigational delivery techniques for treatment of malignant brain tumors.
- Clinical trials using these methods have been completed, with mixed results, and several more are being initiated.
Related Articles
Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
Trends in Pharmacological Sciences, 10/29/09
Relevance Score: 68%
Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis
The International Journal of Tuberculosis and Lung Disease, 11/19/09
Relevance Score: 67%
Optimized inhaler mouthpiece design allows for more effective drug delivery
EurekAlert, 10/22/09
Relevance Score: 67%
Value-Based Insurance Design in Medicare
Applied Health Economics and Health Policy, 10/20/09
Relevance Score: 67%
A Comparison of Phase II Study Strategies
Clinical Cancer Research, 10/01/09
Relevance Score: 67%
Today in Neuro/Psych pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Kinematic improvement following Botulinum Toxin-A injection in upper limb spasticity due to stroke
Journal of Neurology, Neurosurgery, and Psychiatry , 12/07/09
Gabapentin Enacarbil in Restless Legs Syndrome: A Phase 2b, 2-Week, Randomized, Double-Blind, Placebo-Controlled Trial
Clinical Neuropharmacology, 12/07/09
Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP
Epilepsia, 12/07/09
Today in Neurologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
DO Intracranial Neoplasms Differ in Ollier Disease and Maffucci Syndrome? An in-Depth Analysis of the Literature
Neurosurgery, 12/07/09
Antiepileptics in brain metastases: safety, efficacy and impact on life expectancy
Journal of Neuro-Oncology, 12/07/09
High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system
Journal of Neuro-Oncology, 12/07/09