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Biology of angiogenesis and invasion in glioma
Neurotherapeutics, 07/01/09

Tate MC et al. - In a review of the biology of angiogenesis and invasion in glioma, the findings in this article provide renewed hope for those endeavoring to improve treatment of pts with glioma by providing a novel set of rational targets for translational drug discovery.

• Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical challenge, despite modest advances in surgical technique, radiation, and chemotherapeutics.
• Formation of abnormal, dysfunctional tumor vasculature and glioma cell invasion along white matter tracts are believed to be major components of the inability to treat these tumors effectively.

• Recent insight into fundamental processes governing glioma angiogenesis and invasion provide a renewed hope for development of novel strategies aimed at reducing the morbidity of this uniformly fatal disease.
• This article discusses background biology of the blood brain barrier and its pertinence to blood vessel formation and tumor invasion.
• It focuses on the biology of glioma angiogenesis and invasion, and the key mediators of these processes.
• It will briefly discuss recent and ongoing clinical trials targeting mediators of angiogenesis or invasion in glioma patients.

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