Your Article Summary
See Latest Articles3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder
Journal of Psychiatry & Neuroscience , 07/01/09
Andreazza AC et al. - This study indicates a possible tyrosine nitration-induced damage in patients with bipolar disorder that is present from the early stage of illness. This study also indicates that patients in the late stage of illness demonstrate enhanced activity of GR and GST, which could suggest the involvement of a compensatory system in bipolar disorder.
Methods- Matched 30 patients in the early stage and 30 patients in the late stage of bipolar disorder, diagnosed according to DSM-IV criteria, with 60 healthy controls (30 matched for each group of patients).
- Measured symptomatic status using the Hamilton Rating Scale for Depression and the Young Mania Rating Scale.
- We found a significant increase in 3-nitrotyrosine levels among patients in the early (p < 0.010) and late (p < 0.010) stages of bipolar disorder.
- The activity of GR and GST was increased only among patients in the late stage of illness.
- Glutathione peroxidase activity and carbonyl content did not differ among the groups.
Related Articles
Bipolar Disorder Patient Care Opportunities: Let's Answer the Call
Annals of Pharmacotherapy, 10/16/09
Relevance Score: 46%
Safety and Efficacy of Quetiapine in Bipolar Depression
Annals of Pharmacotherapy, 10/13/09
Relevance Score: 46%
Subgenual cingulate volumes in offspring of bipolar parents and in sporadic bipolar patients
European Archives of Psychiatry and Clinical Neuroscience, 10/13/09
Relevance Score: 46%
Predominant polarity and temperament in bipolar and unipolar affective disorders
Journal of Affective Disorders, 11/12/09
Relevance Score: 45%
Epidemiology and Management of Anxiety in Patients with Bipolar Disorder
CNS Drugs, 10/30/09
Relevance Score: 45%
Today in Neuropsych Sciences...keeping you current
Receive free subspecialty "5-minute updates" via email
The APOE gene and cognitive function in non-demented and Alzheimers disease patients
Reviews in Clinical Gerontology, 12/15/09
Single- and Multiple-Domain Amnestic Mild Cognitive Impairment: Two Sides of the Same Coin
Dementia and Geriatric Cognitive Disorders, 12/15/09
Incidence of Parkinson's Disease in Bulgaria
Neuroepidemiology , 12/15/09