Neurology Medical News about Immune senescence

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Immune senescence and brain aging: can rejuvenation of immunity reverse memory loss
Trends in Neurosciences, 07/01/09

Ron-Harel N et al. - Memory loss does not solely reflect chronological age; rather, it is an outcome of the gap between an increasing demand for maintenance (age-related risk-factor accumulation) and the reduced ability of the immune system to meet these needs.

Exclusive Author Commentary
Michal Schwartz, 07/06/09

The immune system is the main maintenance and repair system of the body that can fight various aspects of tissue damage, whether caused by a foreign pathogen or as a result of loss of control on physiological processes, as is the case in cancer. Our group have shown, in oppose to the past consensus, that the CNS is no different in that aspect from the rest of the body and that a well controlled immune activation improves neuronal survival and functional recovery from CNS insults. Moreover, we demonstrated that the peripheral immune system has a pivotal role in CNS maintenance under physiological conditions; Immune deficiency impairs various aspects of brain functional plasticity, characteristic of brain aging, including deterioration in cognitive abilities. Our current opinion article presented here suggests that brain senescence does not necessarily reflect chronological age but the aging of the immune system. This novel view suggests an approach for preventing or slowing-down aging of the brain, by manipulating the peripheral immune system.

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