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Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease
Movement Disorders, 07/01/09

Lee JY et al. – Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of of impulse control and related behaviors (ICRB) in Parkinson's disease (PD).

• Study of whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with appearance of ICRB in PD with dopamine replacement therapy (DRT)
• Survey of ICRB in consecutive Korean pts with PD treated with stable DRT using modified Minnesota Impulsive Disorders Interview over 4 mo
• Subjects: 404 pts who completed interview and 559 Korean healthy normal controls
• Genotyping for variants of DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.-200T>G, and promoter region of the serotonin transporter gene (5-HTTLPR)

• Behavioral abnormalities suggestive of ICRB (compulsive buying, gambling, sexual behavior, eating, punding) in 14.4% of pts
• DRD2 and 5-HTTLPR variants not associated with risk of developing ICRB
• AA genotype of DRD3 p.S9G and CC genotype of GRIN2B c.366C>G more frequent in ICRB vs nonaffected pts
• After controlling for clinical variables in multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B identified as independent risk factor for ICRB

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