Neurology

Your Article Summary

See Latest Articles

Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease
Movement Disorders, 07/01/09

Lee JY et al. – Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of of impulse control and related behaviors (ICRB) in Parkinson's disease (PD).

• Study of whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with appearance of ICRB in PD with dopamine replacement therapy (DRT)
• Survey of ICRB in consecutive Korean pts with PD treated with stable DRT using modified Minnesota Impulsive Disorders Interview over 4 mo
• Subjects: 404 pts who completed interview and 559 Korean healthy normal controls
• Genotyping for variants of DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.-200T>G, and promoter region of the serotonin transporter gene (5-HTTLPR)

• Behavioral abnormalities suggestive of ICRB (compulsive buying, gambling, sexual behavior, eating, punding) in 14.4% of pts
• DRD2 and 5-HTTLPR variants not associated with risk of developing ICRB
• AA genotype of DRD3 p.S9G and CC genotype of GRIN2B c.366C>G more frequent in ICRB vs nonaffected pts
• After controlling for clinical variables in multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B identified as independent risk factor for ICRB

Today in Movement Disorders...keeping you current

Receive free subspecialty "5-minute updates" via email

Severe relapses after the first infusion of natalizumab in active relapsing-remitting multiple sclerosis
Multiple Sclerosis, 10/09/09

Paraplegia Following Image-Guided Transforaminal Lumbar Spine Epidural Steroid Injection: Two Case Reports
Pain Medicine, 10/29/09

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
Brain, 10/09/09

See All of Movement Disorders