Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Doctors and the DEA Free full text
Top Ten Searches
parkinson's neuritis neuralgia myasthenia gravis lactic acidosis ataxia seizure tinnitus migraine hypotoniaYour Article Summary
See Latest ArticlesFulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons
Annals of Neurology , 07/02/09
Wuthrich C et al. - The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. A human immunodeficiency virus-negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non-small-cell lung cancer is presented.
Igor J. Koralnik, 07/07/09
| The polyomavirus JC(JCV) is the etiologic agent of progressive multifocal leukoencephalopathy(PML) and of JCV granule cell neuronopathy(JCV GCN). We present an HIV-negative patient who developed multiple cortical lesions, aphasia and progressive cognitive decline after chemotherapy for non-small-cell lung cancer. Brain biopsy and CSF PCR demonstrated JCV and she had a rapidly fatal outcome. Post-mortem analysis showed diffuse cortical lesions and areas of necrosis at the gray-white junction. Immunostaining revealed a productive JCV-infection of cortical pyramidal neurons, confirmed by electron microscopy, with limited demyelination. This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis. |
Today in CNS Infectious Disease...keeping you current
Receive free subspecialty "5-minute updates" via email
Corticosteroids (dexamethasone versus intravenous methylprednisolone) in patients with tuberculous meningitis
Annals of Tropical Medicine and Parasitology, 10/15/09
Penetration of Colistin into Cerebrospinal Fluid
Antimicrobial Agents and Chemotherapy, 11/05/09
Magnetic resonance imaging in central nervous system tuberculosis
Indian Journal of Radiology and Imaging, 10/29/09
Sponsor
Article Search
Sponsor