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Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age
Annals of Neurology , 06/30/09
Kok E et al. - The prevalence and age dependency of senile plaques (SP) and neurofibrillary tangles (NFT), the brain changes characteristic of Alzheimer disease (AD), and their association with apolipoprotein E (APOE) genotypes in a community-dwelling normal population is studied. The brain changes associated with AD may already begin developing early in middle age, especially among APOEepsilon4 carriers.
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The Clinical Course of Advanced Dementia
New England Journal of Medicine, 10/16/09
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy
European Journal of Neurology, 11/02/09
Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias
Clinical Interventions in Aging, 09/29/09
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