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Intracranial tumors in first year of life: the CHEO experience
Child's Nervous System, 07/01/09

Mehrotra N et al. - Brain tumors in the first year of life represent 4.8% of patients treated at CHEO. Mode of presentation, utilization of adjuvant therapy, and survival depend on tumor location and histology, with worse prognosis for infratentorial lesions. One third of patients had acceptable functional outcome requiring no special assistance.

Exclusive Author Commentary
Michael Vassilyadi, 07/03/09

Brain tumors are rarely diagnosed in infancy with small institutional case series defining the bulk of the collective literature experience. Marked heterogeneity exists among these studies for histological diagnosis and management strategy, reflecting the varied modes of patient presentation and survival, surgeon experience and surgical decision-making, and the small lesion numbers accessible for analysis. The histological variability between different series likely accounts for survival ranging as low as 32% and as high as 81%; our long-term survival rates are in the middle of this range. The mode of presentation, utilization of adjuvant therapy, and survival are all dependent on tumor location and histology, with worse prognosis for infratentorial lesions. One third of patients in this series had excellent Karnofsky outcomes with no requirement for assisted living, with 7 out of 8 of these having had supratentorial tumors.

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Diagnosis and Treatment of Intracranial Immature Teratoma
Pediatric Neurosurgery, 11/13/09 Relevance Score: 66%

Intracranial tumor lysis and cerebral edema after administration of intrathecal methotrexate: a case report and discussion
Medical Oncology, 10/28/09 Relevance Score: 66%

Adult primary spinal cord tumors
Expert Review of Neurotherapeutics, 10/22/09 Relevance Score: 66%

Atypical presentation of chronic granulomatous disease in an adolescent boy with frontal lobe located Aspergillus abscess mimicking intracranial tumor
Child's Nervous System, 10/29/09 Relevance Score: 65%

Giant recurrent glomus jugulotympanicum with intracranial, extracranial, and nasophayngeal extension with emphasis on the imaging role of clinical management
Radiology Case Reports, 10/15/09 Relevance Score: 65%